Research Associate/Senior Research Associate, Hit Validation and Program Enablement

Biomolecular Sciences and Lead Discovery · Cambridge, Massachusetts
Department Biomolecular Sciences and Lead Discovery
Employment Type Full-Time
Minimum Experience Mid-level

Remix Therapeutics is a biotechnology company focused on discovering modulators of RNA processing for undruggable disease drivers with the promise to bring new medicines to patients. We are developing a suite of proprietary platform technologies that transform our ability to design and develop therapeutics that can selectively modulate various steps of RNA processing biology. The company is financed by Atlas Venture, The Column Group, Foresight Capital, Arch Venture Partners, Casdin Capital and Alexandria Venture Investments.

Position Summary:

We seek a highly motivated, B.S. or M.S.-level cell or molecular biologist to join our team located in Cambridge, MA. As a team member of the Biomolecular Sciences and Lead Discovery group, this individual will report to an Associate Director and be responsible for the development, execution, and analysis of various multiplex assays monitoring gene regulation to enable new drug discovery programs at Remix. We are seeking an enthusiastic scientist who can work independently, and as part of a team, in a dynamic innovative startup environment. The ideal candidate will have strong experimental skills and will be expected to contribute to data generation, analysis, interpretation, visualization as well as communicating with a cross-functional team of scientists.

Principal Duties and Responsibilities

  • Design and conduct cell-based experiments for an innovative drug discovery platform to monitor RNA processing events
  • Develop and validate in vitro assays for small molecule hit discovery, as well as elucidating MOA
  • Participate in project team meetings and platform development
  • Maintain detailed records of experimental protocols and data in electronic laboratory notebooks
  • Prioritize activities, manage internal resources while balancing multiple priorities under time and resource constraints
  • Build and maintain productive relationships with colleagues across the broader Remix team


  • B.S. or M.S. in cellular and molecular biology, or a related discipline with 3-5 years of early-stage small molecule drug discovery experience
  • Experience with cell culture, including growing and maintaining adherent and suspension mammalian cell lines, and measurements of cell viability
  • Experience with multiplex assays, including NanoString platform, 384-well qPCR, NGS workflows, and luciferase/GFP reporter systems
  • Experience with transfections/stable expression of shRNA, siRNA and CRISPR as well as treatment with drug-like small molecules
  • Excellent organizational and communication skills with ability to work independently in a multidisciplinary team
  • In-depth knowledge of RNA biology related mechanisms (e.g., splicing, stability, turnover) is highly desired
  • Ability to analyze large datasets and generate figures using R, Python, etc. is also desired
  • Critical thinking, attention to detail, and careful record-keeping

Remix values diversity and is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, marital or veteran status, genetic information, sexual orientation or any other legally protected status. Remix will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Note to Third Party Staffing Agencies: Please do not forward any agency resumes. Remix Therapeutics is not responsible for any fees related to resumes that are unsolicited.

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  • Location
    Cambridge, Massachusetts
  • Department
    Biomolecular Sciences and Lead Discovery
  • Employment Type
  • Minimum Experience